CD133 is one of the most extensively studied cell surface antigens of somatic stem cell populations.
CD133 is expressed by neuroepithelial and radial glial cells in the embryonic mouse brain. ReNcell™ Human Neural Stem Cells are robust immortalized neural stem cell lines derived from developing human brains.ReNcell ® VM and CX cells are generated from the ventral mesencephalon and cortical regions of the brain, respectively, and transduced with the myc transcription factor. CD133 The CD133 (also named AC133) antigen is a 97 kDa glycoprotein, with 5 transmembrane domains, that shows up as a 120 kDa band on protein gels due to glycosylation. Results. József. Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD133 antibody (ab19898) This image is courtesy of an anonymous Abreview CD133+ cells with cancer stem cell characteristics associates with vasculogenic mimicry in triple-negative breast cancer Skip to main content Thank you for visiting nature.com. However, ab19898 has been shown to recognise mouse neural stem cells using ICC. CD133 Fibronectine; GLUT; Islet-1 Musashi 1; Nestin; P75 NGF PAX3; Vimentin. Blocking using the immunising peptide removed both of these bands. 51-52 Similar to NSCs, these BTSCs exhibit self-renewal, high proliferative capacity and multi-lineage differentiation potential in vitro. Here, we report that, in the adult mouse forebrain, immunoreactivity for a neural stem cell marker, prominin-1/CD133, is exclusively localized to the ependyma, although not all ependymal cells are CD133… Neural Stem Cells.
10.1.3 CD133: A Unique Cell Surface Antigen for Cell-Based Therapy and Tissue Engineering. Supporting evidence exists for the derivation of early lineage neural stem or neuroepithelial-like stem cells that are continuously expandable in culture, express over 90% CD133 on the cell surface, and generate predominantly neurons (Koch et al., 2009, Falk et al., 2012). Jászai, ... Christine A. Fargeas, in Neural Surface Antigens, 2015. Multipotent neural stem-like cells, known as brain tumor stem cells (BTSCs) or cancer stem cells (CSCs), have been identified and isolated from different grades (low and high) and types of brain cancers, including gliomas and medulloblastomas.
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